Inhibition of H1N1 Influenza Virus-induced Apoptosis by Ebselen Through ROS-mediated ATM/ATR Signaling PathwaysArticle Published on 2023-06-012023-06-23 Journal: Biological trace element research [Category] 신종인플루엔자, [키워드] Apoptosis Ebselen Influenza mechanism oxidative damage. [DOI] 10.1007/s12011-022-03369-2 PMC 바로가기
Characterization of the SARS-CoV-2 ExoN (nsp14 ExoN –nsp10) complex: implications for its role in viral genome stability and inhibitor identificationAcademicSubjects/SCI00010 Published on 2022-02-222022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, COVID19(2023년), SARS, [키워드] Antiviral assays blocked characterization classical complex coronavirus CoV COVID-19 Ebselen functional Genome genome replication global pandemic HIV identify implication in viral inhibit inhibitor M pro multifunctional non-structural protein nsp14 Proofreading protease RdRP Replication replication fidelity reveal RNA RNA genomes RNA structures RNA-dependent RNA polymerase RNase SARS-CoV-2 SARS-CoV-2 coronavirus stability the SARS-CoV-2 Treatment variety viral genome [DOI] 10.1093/nar/gkab1303 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Structure-Activity Studies Reveal Scope for Optimisation of Ebselen-Type Inhibition of SARS-CoV-2 Main ProteaseArticle Published on 2022-02-162023-07-07 Journal: ChemMedChem [Category] COVID19(2023년), [키워드] COVID-19 Ebselen ebsulfur Mpro inhibition nucleophilic cysteine protease.. SARS-CoV-2 [DOI] 10.1002/cmdc.202100582 PMC 바로가기
Discovery of Camellia sinensis catechins as SARS-CoV-2 3CL protease inhibitors through molecular docking, intra and extra cellular assays분자 도킹, 세포내 및 세포외 분석을 통한 SARS-CoV-2 3CL 프로테아제 억제제로서의 동백나무 카테킨 발견Article Published on 2022-02-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] COVID19(2023년), SARS, 치료기술, [키워드] (-)-epicatechin (–)-epicatechin 3-O-caffeoate 3CL 3CLpro Amino acid amino acid residue amino acid residues ASN142 AutoDock binding energy Camellia Camellia sinensis catechins cellular chymotrypsin conducted configuration cysteine cysteine protease detection system dissociation Dissociation constant Ebselen ebselen. ECG Epicatechin Extracellular gallate GCG GLN189 Gly143 HIS163 inhibit inhibitors inhibitory activity Modification molecular docking Previous studies previous study Protease inhibitor SARS-CoV-2 selected SPR suggested surface plasmon surface plasmon resonance THR26 was used [DOI] 10.1016/j.phymed.2021.153853 PMC 바로가기 [Article Type] Article
The Role of Selenium in Pathologies: An Updated ReviewReview Published on 2022-01-272022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] adverse effects Alzheimer’s disease Amino acid antioxidants Biological functions Cancer Cardiovascular disorders Clinical outcome Concentration COVID-19 diabetes Diseases Ebselen Fertility gender medicine GPx Hormones Infection Inflammation involved Mental Disorders modulating outcome over pathology prognostic reactive oxygen specy reduced risk Regulation reported required review role ROS SARS-CoV-2 Selenium TrxR variety [DOI] 10.3390/antiox11020251 PMC 바로가기 [Article Type] Review
The Se–S Bond Formation in the Covalent Inhibition Mechanism of SARS-CoV-2 Main Protease by Ebselen-like Inhibitors: A Computational Study엡셀렌 유사 억제제에 의한 SARS-CoV-2 주요 프로테아제의 공유 결합 억제 메커니즘에서 Se-S 결합 형성: 전산 연구Article Published on 2021-09-102022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료제, [키워드] antiviral therapies apo form bond canonical catalytic dyad Combination complex covalent bond DFT Donor drug Ebselen Formation functional H-bond His41 hydrogen hydroxyl hydroxyl group inhibition inhibition mechanism knowledge less M pro mechanism member molecular dynamics Molecular dynamics simulation performed position potential energy potential energy surface protease Protease inhibitor SARS-CoV-2 SARS-CoV-2 main protease Se–S covalent bond selective Selenium sulfur theory [DOI] 10.3390/ijms22189792 PMC 바로가기 [Article Type] Article
In silico Studies on the Interaction between Mpro and PLpro From SARS-CoV-2 and Ebselen, its Metabolites and DerivativesSARS-CoV-2와 Ebselen, 그 대사 산물 및 파생물에서 Mpro와 PLpro 간의 상호 작용에 대한 인 실리코 연구Article Published on 2021-08-012022-09-11 Journal: Molecular informatics [Category] SARS, 치료제, [키워드] active sites antiviral drugs carbonyl caused COVID-19 COVID-19 pandemic cysteine density Density functional theory derivative derivatives DFT docking Ebselen electrophilic energetics enzyme Enzyme inhibition Enzymes ethaselen in vitro inhibit inhibitor inhibitors Interaction Jin metabolite molecules MPro Nature nucleophilic organoselenium Papain Papain-like protease PLPro protease Protease. Proteases SARS-CoV-2 target tested the SARS-CoV-2 theory thiol Treatment virus replication [DOI] 10.1002/minf.202100028 PMC 바로가기 [Article Type] Article
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivativesArticle Published on 2021-05-242022-10-04 Journal: Nature Communications [Category] SARS, 치료제, [키워드] Analysis antiviral activity binding mode catalytic dyad Critical crystal structures crystallographic structure cysteine demonstrated derivative derivatives develop Drug discovery and development Ebselen enzyme examined global effort hydrolysis infected cell inhibit inhibition investigated M pro mechanism pandemic protease reactivity SARS-CoV-2 SARS-CoV-2 main protease the SARS-CoV-2 therapeutic these compound triggered viral replication viruses X-ray crystallography zoonotic [DOI] 10.1038/s41467-021-23313-7 PMC 바로가기 [Article Type] Article
Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2Article Published on 2021-02-112022-10-04 Journal: Scientific Reports [Category] 치료제, [키워드] analogue analogues antiviral drugs approach Approximate Bayesian benefit caused compounds coronavirus correlated COVID-19 disease Critical Disease progression Ebselen enzyme enzyme activity Enzymes highly active host’s immune system identification identify Infectious diseases inhibiting inhibitor Medicinal chemistry modulate molecular Molecular modelling novel coronavirus SARS-CoV-2 Papain-like protease protease Proteases Replication SARS-CoV-2 Screening Small molecules Treatment virus replication [DOI] 10.1038/s41598-021-83229-6 PMC 바로가기 [Article Type] Article
Ebselen, a new candidate therapeutic against SARS-CoV-2Comment Published on 2020-12-012023-07-05 Journal: International journal of surgery (London, England) [Category] SARS, [키워드] clinical trials COVID-19 Ebselen main protease Repurposed drug SARS-CoV-2 Therapeutics. [DOI] 10.1016/j.ijsu.2020.10.018 PMC 바로가기 [Article Type] Comment